Multi-omic Acral Melanoma Altas
Acral melanoma (AM) is an aggressive subtype of melanoma with a dismal prognosis. The transition from AM in situ (AMis) to invasive AM (iAM) significantly decreases survival. Here we integrated data from 147 AM patients using six omics approaches that identified four invasion-preferred drivers (NRAS, KRAS, NF1, and KIT) and suggested adnexal involvement as a potential invasive indicator. Two distinct invasion and expansion patterns were found in AM, and notably, one pattern showing enrichment of APOE+/CD163+ macrophages is associated with increased tumor progression and shorter patient survival. This particular macrophage profile promotes tumor cell transition via the IGF1-IGF1R interaction. Our results shed light on the evolutionary dynamics during AM invasion and have important implications for the early detection, prognosis, and treatment of AM.
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About
This data portal is based on framework shiny, shinydashboard, shinyWidgets and shinySky.
If you have any problems, please contact Hengkang Liu (liuhengkang@pku.edu.cn).
Citation
Liu et al., Integrative molecular and spatial analysis reveals evolutionary dynamics and tumor-immune interplay of in situ and invasive acral melanoma, Cancer Cell (2024), https://doi.org/10.1016/j.ccell.2024.04.012
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For any questions about this data portal, please contact Xue lab for more information (E-mail: rxue@hsc.pku.edu.cn)