[Publication in Nature] Liver TIME Subtypes and Neutrophil Heterogeneity.
Novenber 9th 2022. We firstly defined five immune microenvironment subtypes of
liver cancer with single cell precision and reveals the heterogeneity of tumor
associated neutrophils (TAN). We also discovered the tumor promoting mechanism of
two key subtypes, CCL4+ and PD-L1+ TAN, and finally proved that targeting tumor
associated neutrophils is expected to form a new immunotherapy scheme for
liver cancer.
[Full Paper]