People

1988, studied for an undergraduate degree in the Department of chemistry, Peking University, and then transferred to the United States
1991-1995, obtained bachelor's degree and master's degree from the University of Georgia in the United States
2001, graduated from Johns Hopkins University School of medicine with a doctorate in biochemistry, cell and molecular biology
2001-2003, postdoctoral fellow, National Cancer Institute
2003-2005, associate professor, Department of chemical biology, School of chemistry, Peking University
2005-2007, served as an assistant professor at the University of Auckland in the United States
2007-2008, served as deputy director of the Cancer Hospital Affiliated to Tianjin Medical University and Tianjin Cancer Research Institute, and director of the central laboratory
2008-2017, served as the director of Tianjin basic medical research center
2010-2017, served as vice president of Tianjin Medical University and director of Tianjin basic medical research center
2017, he was appointed deputy director of the Department of medicine of Peking University. In charge of scientific research, equipment and laboratory management
He has been engaged in basic and applied research of tumor for a long time. Academic research has been recognized by peers at home and abroad, and 112 academic papers have been published in science, cancer cell, Gastroenterology, Hepatology, JCI, ACS Nano, genome research, nature communication, PNAs and other magazines. The article was selected into the 2019 China annual paper of cell press.

Johns Hopkins University School of Medicine received a doctor's degree, completed the post doctoral training of CrTa at NIH, and is currently a professor of Peking University. He has been engaged in basic and applied research of tumor for a long time. Academic research has been recognized by peers at home and abroad, and 112 academic papers have been published in science, cancer cell, Gastroenterology, Hepatology, JCI, ACS Nano, genome research, nature communication, PNAs and other magazines. The article was selected into the 2019 China annual paper of cell press. It was selected into the national "ten thousand talents plan" and supported by the National Science Fund for Distinguished Young Scholars. Executive deputy editor of cancer biology & medicine. It has been supported by scientific research projects of the National Natural Science Foundation of China and the Ministry of science and technology for a long time.

Representative articles in recent 5 years
Xue R#, Chen L#, Zhang C#, …Zeng M*, Bai F*, Zhang N*. Genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes. Cancer Cell. 2019 Jun 10;35(6):932-947.
Gao Y, Ni X, Guo H, Su Z, Ba Y, Tong Z, Guo Z, Yao X, Chen X, Yin J, Yan Z, Guo L, Liu Y, Bai F, Xie XS, Zhang N*. Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumour cells. Genome Res. 2017 May 9
Wang C, Li Y, Yan S, Wang H, Shao X, Xiao M, Yang B, Qin G, Kong R, Chen R*, and Zhang N*. Interactome Analysis Reveals that LncRNA HULC Promotes Aerobic Glycolysis through LDHA and PKM2. Nature Communications, 2020.
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Received a doctor's degree from the Cancer Institute of the medical college and is now a researcher in the first hospital of Peking University. She has been engaged in basic tumor biology and anticancer drug research for a long time. Academic research has been recognized by peers at home and abroad, and has published more than 30 academic papers in science, Journal of clinical investigation, cancer research, oncogene and other magazines. Won the "excellent young scientists" project of the National Natural Science Foundation of China and the "outstanding young scientists" of the Chinese Academy of Sciences; Presided over the general projects of the National Natural Science Foundation of China.

Representative articles in recent 5 years
Rong Liu*, Peiguo Shi, Zhongmei Zhou, Hailin Zhang, Wei Li, Hong Zhang, and Ceshi Chen*, Krüpple-like factor 5 is essential for mammary gland development and tumorigenesis, J Pathol, 2018 Dec, 246(4):497-507
uqi Lin, Rong Liu,* Ping Zhao, Zheng Zheng, Jingan Huang, Yingying Zhang, Yu Gao, Haiying Chen, Suling Liu, Jia Zhou,* Ceshi Chen,* Haijun Chen*, Discovery of Novel Mifepristone Derivatives via Suppressing KLF5 Expression for the Treatment of Triple-Negative Breast Cancer, Eur J Med Che, 2018 Feb 25;146:354-367.
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Received a doctor's degree from the school of oncology of Peking University and served as an associate researcher at the Institute of Biophysics, Chinese Academy of Sciences. She is now an associate researcher at the first hospital of Peking University and has been engaged in the mechanism research of molecular biology and tumor biology for a long time. Academic research has been recognized by peers at home and abroad. It has published 8 papers as the co first author / corresponding author, including academic journals such as journal of clinical investigation, and applied for a patent. Presided over a number of National Natural Science and Beijing Natural Science Foundation projects.

Representative articles in recent 5 years
Wang C, Li Y, Yan S, Wang H, Shao X, Xiao M, Yang B, Qin G, Kong R, Chen R*, and Zhang N*. Interactome Analysis Reveals that LncRNA HULC Promotes Aerobic Glycolysis through LDHA and PKM2. Nature Communications, 2020.
Dong X, Feng M, Yang H, Liu H, Guo H, Gao X, Liu Y, Liu R, Zhang N, Chen R, Kong R*. Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma. Int J Biol Sci. 2020
Chen X, Fan Z, McGee W, Chen M, Kong R, Wen P, Xiao T, Chen X, Liu J, Zhu L, Chen R, Wu JY. TDP-43 regulates cancer-associated microRNAs. Protein Cell. 2018 Close

He received a doctor's degree from the school of life sciences of Peking University and is now an associate researcher of the first hospital of Peking University. It has been committed to using advanced genome / single cell sequencing technology and bioinformatics analysis methods to explore the occurrence and development of tumors. Academic research has been recognized by peers at home and abroad, and has made a series of scientific research achievements in the field of liver cancer heterogeneity and clonal evolution. He has published 9 papers as the co first author / corresponding author, including well-known academic journals such as cancer cell, Gastroenterology, nature communications, thorax, etc., and has received special comments and attention from important journals such as Nature Reviews, Gastroenterology & Hepatology, cell, etc, The research paper was selected as the "2019 China annual paper of cell press". He has made oral reports at international conferences for many times, won the Young Investigator Award of the International Association for tumor metastasis, and the star of hope for scientific research of Peking University Hospital. He presided over and participated in a number of National Natural Science and science and Technology Ministry funds.

Representative articles in recent 5 years
Xue R#, Chen L#, Zhang C#, …Zeng M*, Bai F*, Zhang N*. Genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes. Cancer Cell. 2019 Jun 10;35(6):932-947.
Zhang C#, Zhang L#, Xu T#, Xue R#, Yu L#, Zhu Y, Wu Y, Zhang Q, Li D, Shen S, Tan D, Bai F, Zhang H. Mapping the spreading routes of lymphatic metastases in human colorectal cancer. Nature Communications.2020
Li R#, Li X#, Xue R#, Yang F#, Wang S, Li Y, Shen D, Sun K, Chen K, Weng W, Bai F, Wang J. Early metastasis detected in patients with multifocal pulmonary ground-glass opacities (GGOs). Thorax. 2018 Close

Team Members